Tolerogenic pDCs: spotlight on Foxo3

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Tolerogenic pDCs: spotlight on Foxo3.

Cancer creates a peculiar inflammatory environment enriched for transcription factors with a negative influence on adaptive immunity. In this issue of the JCI, Watkins and colleagues identify Foxo3 as a master regulator of the tolerogenic program in tumor-associated, plasmacytoid DCs (pDCs). Foxo3 enables pDCs to induce tolerance in tumor antigen-specific CD8+ T cells, turning them into regulat...

متن کامل

A Spotlight on Spotlight

In this paper, we have made an attempt to take a look under the hood of Spotlight and understand some of the following questions amongst others: • How well-integrated is Spotlight with the file system? • How reliable is the interface between Spotlight and the file system? • Is live update a myth or a reality under heavy file system activity? Based on our experiments, it seems that Spotlight is ...

متن کامل

Retraction. FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer.

The limited success of cancer immunotherapy is often attributed to the loss of antigen-specific T cell function in situ. However, the mechanism for this loss of function is unknown. In this study, we describe a population of tumor-associated DCs (TADCs) in both human and mouse prostate cancer that tolerizes and induces suppressive activity in tumor-specific T cells. In tumors from human prostat...

متن کامل

Foxo3

Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potential target for immunotherapy.

متن کامل

Spotlight on Knowledge SPOTLIGHT ON KNOWLEDGE: DOMESTIC VIOLENCE

In this paper, Adomako Ampofo discusses the activism and struggles that gave birth to the domestic violence law in Ghana. A professor in African Studies and a women’s rights activist herself, Adomako Ampofo traces the trajectory of Ghanaian women organizing for change from the pre-colonial period, through the independent struggles to the passage of the domestic violence bill into law. She parti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 2011

ISSN: 0021-9738

DOI: 10.1172/jci57190